A List of papers published by our lab (since 1943) and current lab members. For the latest information, please click here (PubMed).

Actin-binding protein Filamin B regulates the cell-surface retention of endothelial sphingosine 1-phosphate receptor 1
Zhao X, Kiyozuka K, Konishi A, Reika Kawabata-Iwakawa, Minamishima YA, Obinata H.
J Biol Chem. 2023 May 21. doi: 10.1016/j.jbc.2023.104851.

Inactivation of ackA and pta Genes Reduces GlpT Expression and Susceptibility to Fosfomycin in Escherichia coli
Hirakawa H, Takita A, Sato Y, Hiramoto S, Hashimoto Y, Ohshima N, Minamishima YA, Murakami M, Tomita H.
Microbiol Spectr. 2023 May 18:e0506922. doi: 10.1128/spectrum.05069-22.

Crucial role of iron in epigenetic rewriting during adipocyte differentiation mediated by JMJD1A and TET2 activity.
Suzuki T, Komatsu T, Shibata H, Tanioka A, Vargas D, Kawabata-Iwakawa R, Miura F, Masuda S, Hayashi M, Tanimura-Inagaki K, Morita S, Kohmaru J, Adachi K, Tobo M, Obinata H, Hirayama T, Kimura H, Sakai J, Nagasawa H, Itabashi H, Hatada I, Ito T, Inagaki T.
Nucleic Acids Res. 2023 May 9:gkad342. doi: 10.1093/nar/gkad342.

Apolipoprotein M supports S1P production and conservation and mediates prolonged Akt activation via S1PR1 and S1PR3
Kiyozuka K, Zhao X, Konishi A, Minamishima YA, Obinata H.
J Biochem. 2023 Apr 25. doi: 10.1093/jb/mvad037.

Estimation of the Depletion Layer Thickness in Silicon Nanowire-Based Biosensors from Attomolar-Level Biomolecular Detection
Zhang H, Qiu Y, Osawa F, Itabashi M, Ohshima N, Kajisa T, Sakata T, Izumi T, Sone H.
ACS Appl Mater Interfaces. 2023 Apr 12. doi: 10.1021/acsami.3c00202.

PPARα activation partially drives NAFLD development in liver-specific Hnf4a-null mice
Kasano-Camones CI, Takizawa M, Ohshima N, Saito C, Iwasaki W, Nakagawa Y, Fujitani Y, Yoshida R, Saito Y, Izumi T, Terawaki SI, Sakaguchi M, Gonzalez FJ, Inoue Y.
J Biochem. 2023 Jan 23. doi: 10.1093/jb/mvad005.

The development of drugs targeting HIF against tumor cells with VHL mutation: the story of 127 years
Takamori H, Yamasaki T, Kitadai R, Minamishima YA, Nakamura E.
Cancer Sci. 2023 Jan 17. doi: 10.1111/cas.15728.

2,2,6,6-Tetramethylpiperidine-1-oxyl acts as a volatile inhibitor of ferroptosis and neurological injury
Mizuno H, Kubota C, Takigawa Y, Shintoku R, Kannari N, Muraoka T, Obinata H, Yoshimoto Y, Kanazawa M, Koshiishi I, Torii S.
J Biochem. 2022 Jul 25;172(2):71-78. doi: 10.1093/jb/mvac044.

Impact of GAD65 and/or GAD67 deficiency on perinatal development in rats
Jiang W, Kakizaki T, Fujihara K, Miyata S, Zhang Y, Suto T, Kato D, Saito S, Shibasaki K, Ishizaki Y, Isoda K, Yokoo H, Obinata H, Hirano T, Miyasaka Y, Mashimo T, Yanagawa Y.
FASEB J. 2022 Feb;36(2):e22123. doi: 10.1096/fj.202101389R.

⁶⁴Cu-ATSM Predicts Efficacy of Carbon Ion Radiotherapy Associated with Cellular Antioxidant Capacity
Nachankar A, Oike T, Hanaoka H, Kanai A, Sato H, Yoshida Y, Obinata H, Sakai M, Osu N, Hirota Y, Takahashi A, Shibata A, Ohno T.
Cancers (Basel). 2021 Dec 7;13(24):6159. doi: 10.3390/cancers13246159.

Reduced Fatty Acid Use from CD36 Deficiency Deteriorates Streptozotocin-Induced Diabetic Cardiomyopathy in Mice
Jiang W, Kakizaki T, Fujihara K, Miyata S, Zhang Y, Suto T, Kato D, Saito S, Shibasaki K, Ishizaki Y, Isoda K, Yokoo H, Obinata H, Hirano T, Miyasaka Y, Mashimo T, Yanagawa Y.
Metabolites. 2021 Dec 17;11(12):881. doi: 10.3390/metabo11120881.

Characterization of recombinant murine GDE4 and GDE7, enzymes producing lysophosphatidic acid and/or cyclic phosphatidic acid
Tserendavga B, Ohshima N, Fujita C, Yuzawa K, Ohshima M, Yanaka N, Minamishima YA, Izumi T.
J Biochem. 2021 Jan 7;170(6):713-727. doi: 10.1093/jb/mvab091.

Disordered branched chain amino acid catabolism in pancreatic islets is associated with postprandial hypersecretion of glucagon in diabetic mice: Postprandial hypersecretion of glucagon in diabetes.
Wada E, Kobayashi M, Kohno D, Kikuchi O, Suga T, Matsui S, Yokota-Hashimoto H, Honzawa N, Ikeuchi Y, Tsuneoka H, Hirano T, Obinata H, Sasaki T, Kitamura T.
J Nutr Biochem. 2021 Jun 28. doi: 10.1016/j.jnutbio.2021.108811.

CLIC1 and CLIC4 mediate endothelial S1P receptor signaling to facilitate Rac1 and RhoA activity and function.
Mao Y, Kleinjan ML, Jilishitz I, Swaminathan B, Obinata H, Komarova YA, Bayless KJ, Hla T, Kitajewski JK.
Sci Signal. 2021 Apr 20;14(679):eabc0425.

High-Precision Automated Workflow for Urinary Untargeted Metabolomic Epidemiology.
Meister I, Zhang P, Sinha A, Sköld CM, Wheelock ÅM, Izumi T, Chaleckis R, Wheelock CE.
Anal Chem. 2021 Mar 30;93(12):5248-5258.

Global knockdown of glutamate decarboxylase 67 elicits emotional abnormality in mice.
Miyata S, Kakizaki T, Fujihara K, Obinata H, Hirano T, Nakai J, Tanaka M, Itohara S, Watanabe M, Tanaka KF, Abe M, Sakimura K, Yanagawa Y.
Mol Brain. 2021 Jan 7;14(1):5.

Simultaneous capillary electrophoresis of anions and cations in a single injection using an anion exchanger-modified capillary for determination of salivary ions in combination with statistical analyses.
Mori M, Aoyagi K, Tomoda T, Ishikawara F, Sakamoto S, Myochin H, Kuga M, Kozaki D, Ohshima N, Izumi T, Itabashi H, Shoho Y, Yoshida A, Tsunekawa K, Kimura T, Murakami M.
J Chromatogr A. 2020 Oct 29;1635:461647.

Reduced fatty acid uptake aggravates cardiac contractile dysfunction in streptozotocin-induced diabetic cardiomyopathy.
Umbarawan Y, Kawakami R, Syamsunarno MRAA, Koitabashi N, Obinata H, Yamaguchi A, Hanaoka H, Hishiki T, Hayakawa N, Sunaga H, Matsui H, Kurabayashi M, Iso T.
Sci Rep. 2020 Nov 30;10(1):20809.

Design and Fabrication of Silicon Nanowire-Based Biosensors with Integration of Critical Factors: Toward Ultrasensitive Specific Detection of Biomolecules.
Zhang H, Kikuchi N, Ohshima N, Kajisa T, Sakata T, Izumi T, Sone H.
ACS Appl Mater Interfaces. 2020 Nov 18;12(46):51808-51819.

Production of ROS by Gallic Acid Activates KDM2A to Reduce rRNA Transcription.
Tanaka Y, Obinata H, Konishi A, Yamagiwa N, Tsuneoka M.
Cells. 2020. Oct 10;9(10):2266.

CD36 Expression Is Associated With Cancer Aggressiveness and Energy Source in Esophageal Squamous Cell Carcinoma.
Yoshida T, Yokobori T, Saito H, Kuriyama K, Kumakura Y, Honjo H, Hara K, Sakai M, Miyazaki T, Obinata H, Erkhem-Ochir B, Gombodorj N, Sohda M, Saeki H, Kuwano H, Shirabe K.
Ann Surg Oncol. 2020 doi: 10.1245/s10434-020-08711-3

CD8⁺ regulatory T cells are critical in prevention of autoimmune-mediated diabetes.
Shimokawa C, Kato T, Takeuchi T, Ohshima N, Furuki T, Ohtsu Y, Suzue K, Imai T, Obi S, Olia A, Izumi T, Sakurai M, Arakawa H, Ohno H, Hisaeda H.
Nat Commun. 2020 Apr 22;11(1):1922.

The role of autonomously secreted PGE₂ and its autocrine/paracrine effect on bone matrix mineralization at the different stages of differentiating MC3T3-E1 cells.
Suzuki H, Ohshima N, Tatei K, Taniguchi T, Sato S, Izumi T.
Biochem Biophys Res Commun. 2020 Apr 16;524(4):929-935.

Furry protein suppresses nuclear localization of yes-associated protein (YAP) by activating NDR kinase and binding to YAP.
Irie K, Nagai T, Mizuno K.
J Biol Chem. 2020 Mar 6;295(10):3017-3028.

Metformin activates KDM2A to reduce rRNA transcription and cell proliferation by dual regulation of AMPK activity and intracellular succinate level.
Tanaka Y, Konishi A, Obinata H, Tsuneoka M.
Sci Rep. 2019 Dec 10;9(1):18694.

Activation of the Sphingosine 1 Phosphate-Rho Pathway in Pterygium and in Ultraviolet-Irradiated Normal Conjunctiva.
Igarashi N, Honjo M, Fujishiro T, Toyono T, Ono T, Mori Y, Miyata K, Obinata H, Aihara M.
Int J Mol Sci. 2019 Sep 20;20(19). pii: E4670.

Identification of ApoA4 as a sphingosine 1-phosphate chaperone in ApoM- and albumin-deficient mice.
Obinata H, Kuo A, Wada Y, Swendeman S, Liu CH, Blaho VA, Nagumo R, Satoh K, Izumi T, Hla T.
J Lipid Res. 2019 Nov;60(11):1912-1921.

Light Stress-Induced Increase of Sphingosine 1-Phosphate in Photoreceptors and Its Relevance to Retinal Degeneration.
Terao R, Honjo M, Ueta T, Obinata H, Izumi T, Kurano M, Yatomi Y, Koso H, Watanabe S, Aihara M.
Int J Mol Sci. 2019 Jul 26;20(15). pii: E3670. doi: 10.3390/ijms20153670.

Sphingosine 1-phosphate and inflammation.
Obinata H, Hla T.
Int Immunol. 2019 Apr 11;pii: dxz037.

Regulation of MC3T3-E1 differentiation by actin cytoskeleton through lipid mediators reflecting the cell differentiation stage.
Suzuki H, Tatei K, Ohshima N, Sato S, Izumi T.
Biochem Biophys Res Commun. 2019 Jun 25;514(2):393-400.

GDE5 Inhibition Accumulates Intracellular Glycerophosphocholine and Suppresses Adipogenesis at a Mitotic Clonal Expansion Stage.
Okazaki Y, Nakamura K, Takeda S, Yoshizawa I, Yoshida F, Ohshima N, Izumi T, Klein JD, Kumrungsee T, Sands JM, Yanaka N.
Am J Physiol Cell Physiol. 2019 Feb 1;316(2):C162-C174

Failure to sense energy depletion may be a novel therapeutic target in chronic kidney disease.
Kikuchi H, Sasaki E, Nomura N, Mori T, Minamishima YA, Yoshizaki Y, Takahashi N, Furusho T, Arai Y, Mandai S, Yamashita T, Ando F, Maejima Y, Isobe K, Okado T, Rai T, Uchida S, Sohara E.
Kidney Int. 2018 Nov 13. pii: S0085-2538(18)30635-5.

Myocardial fatty acid uptake through CD36 is indispensable for sufficient bioenergetic metabolism to prevent progression of pressure overload-induced heart failure.
Umbarawan Y, Syamsunarno MRAA, Koitabashi N, Obinata H, Yamaguchi A, Hanaoka H, Hishiki T, Hayakawa N, Sano M, Sunaga H, Matsui H, Tsushima Y, Suematsu M, Kurabayashi M, Iso T.
Sci Rep. 2018 Aug 13;8(1):12035.

Glucose is preferentially utilized for biomass synthesis in pressure-overloaded hearts: evidence from fatty acid-binding protein-4 and -5 knockout mice.
Umbarawan Y, Syamsunarno MRAA, Koitabashi N, Yamaguchi A, Hanaoka H, Hishiki T, Nagahata-Naito Y, Obinata H, Sano M, Sunaga H, Matsui H, Tsushima Y, Suematsu M, Kurabayashi M, Iso T.
Cardiovasc Res. 2018 Jul 1;114(8):1132-1144.

Dram1 regulates DNA damage-induced alternative autophagy.
Nagata M, Arakawa S, Yamaguchi H, Torii S, Endo H, Tsujioka M, Honda S, Nishida Y, Konishi A, Shimizu S.
Cell Stress. 2018 Mar 7;2(3):55-65.

Inhibition of Phosphorylated c-Jun NH(2)-terminal Kinase by 2′,4′-dihydroxy-6-methoxy-3,5-dimethylchalcone Isolated from Eugenia aquea Burm f. Leaves in Jurkat T-cells.
Barliana MI, Diantini A, Subarnas A, Abdulah R, Izumi T.
Pharmacogn Mag. 2017 Oct;13(Suppl 3):S573-S577.

Robust suppression of cardiac energy catabolism with marked accumulation of energy substrates during lipopolysaccharide-induced cardiac dysfunction in mice.
Umbarawan Y, Syamsunarno MRAA, Obinata H, Yamaguchi A, Sunaga H, Matsui H, Hishiki T, Matsuura T, Koitabashi N, Obokata M, Hanaoka H, Haque A, Kunimoto F, Tsushima Y, Suematsu M, Kurabayashi M, Iso T.
Metabolism. 2017 Dec;77:47-57.

Metabolic activity by ¹⁸F-FDG-PET/CT is predictive of early response after nivolumab in previously treated NSCLC.
Kaira K, Higuchi T, Naruse I, Arisaka Y, Tokue A, Altan B, Suda S, Mogi A, Shimizu K, Sunaga N, Hisada T, Kitano S, Obinata H, Yokobori T, Mori K, Nishiyama M, Tsushima Y, Asao T.
Eur J Nucl Med Mol Imaging. 2018 Jan;45(1):56-66.

An engineered S1P chaperone attenuates hypertension and ischemic injury.
Swendeman SL, Xiong Y, Cantalupo A, Yuan H, Burg N, Hisano Y, Cartier A, Liu CH, Engelbrecht E, Blaho V, Zhang Y, Yanagida K, Galvani S, Obinata H, Salmon JE, Sanchez T, Di Lorenzo A, Hla T.
Sci Signal. 2017 Aug 15;10(492). pii: eaal2722.

Targeting Oxygen-Sensing Prolyl Hydroxylase for Metformin-Associated Lactic Acidosis Treatment.
Oyaizu-Toramaru T, Suhara T, Hayakawa N, Nakamura T, Kubo A, Minamishima S, Yamaguchi K, Hishiki T, Morisaki H, Suematsu M, Minamishima YA.
Mol Cell Biol. 2017 Jul 28;37(16). pii: e00248-17.

Autophagy controls centrosome number by degrading Cep63.
Watanabe Y, Honda S, Konishi A, Arakawa S, Murohashi M, Yamaguchi H, Torii S, Tanabe M, Tanaka S, Warabi E, Shimizu S.
Nat Commun. 2016 Nov 21;7:13508.

Obesity-induced kidney injury is attenuated by amelioration of aberrant PHD2 activation in proximal tubules.
Futatsugi K, Tokuyama H, Shibata S, Naitoh M, Kanda T, Minakuchi H, Yamaguchi S, Hayashi K, Minamishima YA, Yanagita M, Wakino S, Itoh H.
Sci Rep. 2016 Nov 9;6:36533.

Acquired platinum resistance involves epithelial to mesenchymal transition through ubiquitin ligase FBXO32 dysregulation.
Tanaka N, Kosaka T, Miyazaki Y, Mikami S, Niwa N, Otsuka Y, Minamishima YA, Mizuno R, Kikuchi E, Miyajima A, Sabe H, Okada Y, Uhlén P, Suematsu M, Oya M.
JCI Insight. 2016 Nov 3;1(18):e83654.

Enzymatic characterization of recombinant rat DDHD2: a soluble diacylglycerol lipase.
Araki M, Ohshima N, Aso C, Konishi A, Obinata H, Tatei K, Izumi T.
J Biochem. 2016 Nov;160(5):269-279.

TRF2 Protein Interacts with Core Histones to Stabilize Chromosome Ends.
Konishi A, Izumi T, Shimizu S.
J Biol Chem. 2016 Sep 23;291(39):20798-810.

Impaired endothelial barrier function in apolipoprotein M-deficient mice is dependent on sphingosine-1-phosphate receptor 1.
Christensen PM, Liu CH, Swendeman SL, Obinata H, Qvortrup K, Nielsen LB, Hla T, Di Lorenzo A, Christoffersen C.
FASEB J. 2016 Jun;30(6):2351-9.

Protein purification and cloning of diacylglycerol lipase from rat brain.
Aso C, Araki M, Ohshima N, Tatei K, Hirano T, Obinata H, Kishi M, Kishimoto K, Konishi A, Goto F, Sugimoto H, Izumi T.
J Biochem. 2016 Jun;159(6):585-97.

Inhibition of the oxygen sensor PHD2 in the liver improves survival in lactic acidosis by activating the Cori cycle.
Suhara T, Hishiki T, Kasahara M, Hayakawa N, Oyaizu T, Nakanishi T, Kubo A, Morisaki H, Kaelin WG Jr, Suematsu M, Minamishima YA.
Proc Natl Acad Sci U S A. 2015 Sep 15;112(37):11642-7.

Nogo-B regulates endothelial sphingolipid homeostasis to control vascular function and blood pressure.
Cantalupo A, Zhang Y, Kothiya M, Galvani S, Obinata H, Bucci M, Giordano FJ, Jiang XC, Hla T, Di Lorenzo A.
Nat Med. 2015 Sep;21(9):1028-1037.

HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1 to limit vascular inflammation.
Galvani S, Sanson M, Blaho VA, Swendeman SL, Obinata H, Conger H, Dahlbäck B, Kono M, Proia RL, Smith JD, Hla T.
Sci Signal. 2015 Aug 11;8(389):ra79. doi: 10.1126/scisignal.aaa2581. Erratum in: Sci Signal. 2015 Oct 27;8(400):er8.

New members of the mammalian glycerophosphodiester phosphodiesterase family: GDE4 and GDE7 produce lysophosphatidic acid by lysophospholipase D activity.
Ohshima N, Kudo T, Yamashita Y, Mariggiò S, Araki M, Honda A, Nagano T, Isaji C, Kato N, Corda D, Izumi T, Yanaka N.
J Biol Chem. 2015 Feb 13;290(7):4260-71.

Nicotine exposure alters human vascular smooth muscle cell phenotype from a contractile to a synthetic type.
Yoshiyama S, Chen Z, Okagaki T, Kohama K, Nasu-Kawaharada R, Izumi T, Ohshima N, Nagai T, Nakamura A.
Atherosclerosis. 2014 Dec;237(2):464-70.

Individual variation of human S1P₁ coding sequence leads to heterogeneity in receptor function and drug interactions.
Obinata H, Gutkind S, Stitham J, Okuno T, Yokomizo T, Hwa J, Hla T.
J Lipid Res. 2014 Dec;55(12):2665-75.

Combination of postmortem mass spectrometry imaging and genetic analysis reveals very long-chain acyl-CoA dehydrogenase deficiency in a case of infant death with liver steatosis.
Takahashi Y, Sano R, Nakajima T, Kominato Y, Kubo R, Takahashi K, Ohshima N, Hirano T, Kobayashi S, Shimada T, Tokue H, Awata S, Hirasawa S, Ishige T.
Forensic Sci Int. 2014 Nov;244:e34-7.

The emerging physiological roles of the glycerophosphodiesterase family.
Corda D, Mosca MG, Ohshima N, Grauso L, Yanaka N, Mariggiò S.
FEBS J. 2014 Feb;281(4):998-1016.

Prolyl-hydroxylase PHD3 interacts with pyruvate dehydrogenase (PDH)-E1β and regulates the cellular PDH activity.
Kikuchi D, Minamishima YA, Nakayama K.
Biochem Biophys Res Commun. 2014 Aug 22;451(2):288-94.

Expression pattern of class I phosphoinositide 3-kinase and distribution of its product, phosphatidylinositol-3,4,5-trisphosphate, during Drosophila embryogenesis.
Xi X, Tatei K, Kihara Y, Izumi T.
Gene Expr Patterns. 2014 Jul;15(2):88-95.

Neutralization of leukotriene C4 and D4 activity by monoclonal and single-chain antibodies.
Kawakami Y, Hirano S, Kinoshita M, Otsuki A, Suzuki-Yamamoto T, Suzuki M, Kimoto M, Sasabe S, Fukushima M, Kishimoto K, Izumi T, Oga T, Narumiya S, Sugahara M, Miyano M, Yamamoto S, Takahashi Y.
Biochim Biophys Acta. 2014 Jun;1840(6):1625-33.

Energy management by enhanced glycolysis in G1-phase in human colon cancer cells in vitro and in vivo.
Bao Y, Mukai K, Hishiki T, Kubo A, Ohmura M, Sugiura Y, Matsuura T, Nagahata Y, Hayakawa N, Yamamoto T, Fukuda R, Saya H, Suematsu M, Minamishima YA.
Mol Cancer Res. 2013 Sep;11(9):973-85.

Fine-tuning S1P therapeutics.
Obinata H, Hla T.
Chem Biol. 2012 Sep 21;19(9):1080-2.

Flow-regulated endothelial S1P receptor-1 signaling sustains vascular development.
Jung B, Obinata H, Galvani S, Mendelson K, Ding BS, Skoura A, Kinzel B, Brinkmann V, Rafii S, Evans T, Hla T.
Dev Cell. 2012 Sep 11;23(3):600-10.

Assessment of sphingosine-1-phosphate activity in biological samples by receptor internalization and adherens junction formation.
Obinata H, Hla T.
Methods Mol Biol. 2012;874:69-76.

Involvement of Beclin 1 in engulfment of apoptotic cells.
Konishi A, Arakawa S, Yue Z, Shimizu S.
J Biol Chem. 2012 Apr 20;287(17):13919-29.

Sphingosine 1-phosphate in coagulation and inflammation.
Obinata H, Hla T.
Semin Immunopathol. 2012 Jan;34(1):73-91.

Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1.
Lin W, Cao J, Liu J, Beshiri ML, Fujiwara Y, Francis J, Cherniack AD, Geisen C, Blair LP, Zou MR, Shen X, Kawamori D, Liu Z, Grisanzio C, Watanabe H, Minamishima YA, Zhang Q, Kulkarni RN, Signoretti S, Rodig SJ, Bronson RT, Orkin SH, Tuck DP, Benevolenskaya EV, Meyerson M, Kaelin WG Jr, Yan Q.
Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13379-86.

Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M.
Christoffersen C, Obinata H, Kumaraswamy SB, Galvani S, Ahnström J, Sevvana M, Egerer-Sieber C, Muller YA, Hla T, Nielsen LB, Dahlbäck B.
Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9613-8.

Loss of hypoxia-inducible factor prolyl hydroxylase activity in cardiomyocytes phenocopies ischemic cardiomyopathy.
Moslehi J, Minamishima YA, Shi J, Neuberg D, Charytan DM, Padera RF, Signoretti S, Liao R, Kaelin WG Jr.
Circulation. 2010 Sep 7;122(10):1004-16.

Reactivation of hepatic EPO synthesis in mice after PHD loss.
Minamishima YA, Kaelin WG Jr.
Science. 2010 Jul 23;329(5990):407.

A novel glycerophosphodiester phosphodiesterase, GDE5, controls skeletal muscle development via a non-enzymatic mechanism.
Okazaki Y, Ohshima N, Yoshizawa I, Kamei Y, Mariggiò S, Okamoto K, Maeda M, Nogusa Y, Fujioka Y,Izumi T, Ogawa Y, Shiro Y, Wada M, Kato N, Corda D, Yanaka N.
J Biol Chem. 2010 Sep 3;285(36):27652-63.

Detection of G protein-coupled receptor-mediated cellular response involved in cytoskeletal rearrangement using surface plasmon resonance.
Chen K, Obinata H, Izumi T.
Biosens Bioelectron. 2010 Mar 15;25(7):1675-80.

Identification and analysis of two splice variants of human G2A generated by alternative splicing.
Ogawa A, Obinata H, Hattori T, Kishi M, Tatei K, Ishikawa O, Izumi T.
J Pharmacol Exp Ther. 2010 Feb;332(2):469-78.

A feedback loop involving the Phd3 prolyl hydroxylase tunes the mammalian hypoxic response in vivo.
Minamishima YA, Moslehi J, Padera RF, Bronson RT, Liao R, Kaelin WG Jr.
Mol Cell Biol. 2009 Nov;29(21):5729-41.

Hydrogen sulfide improves survival after cardiac arrest and cardiopulmonary resuscitation via a nitric oxide synthase 3-dependent mechanism in mice.
Minamishima S, Bougaki M, Sips PY, Yu JD, Minamishima YA, Elrod JW, Lefer DJ, Bloch KD, Ichinose F.
Circulation. 2009 Sep 8;120(10):888-96.

Thioesterase activity and subcellular localization of acylprotein thioesterase 1/lysophospholipase 1.
Hirano T, Kishi M, Sugimoto H, Taguchi R, Obinata H, Ohshima N, Tatei K, Izumi T.
Biochim Biophys Acta. 2009 Aug;1791(8):797-805.

Ceramide induces myogenic differentiation and apoptosis in Drosophila Schneider cells.
Kawamura H, Tatei K, Nonaka T, Obinata H, Hattori T, Ogawa A, Kazama H, Hamada N, Funayama T, Sakashita T, Kobayashi Y, Nakano T, Izumi T.
J Radiat Res. 2009 Mar;50(2):161-9.

G2A as a receptor for oxidized free fatty acids.
Obinata H, Izumi T.
Prostaglandins Other Lipid Mediat. 2009 Sep;89(3-4):66-72.

Proteomic analysis identifies proteins that continue to grow hepatic stem-like cells without differentiation.
Saheki T, Ito H, Sekiguchi A, Nishina A, Sugiyama T, Izumi T, Kojima I.
Cytotechnology. 2008 Jun;57(2):137-43.

CDK5-dependent phosphorylation of the Rho family GTPase TC10(alpha) regulates insulin-stimulated GLUT4 translocation.
Okada S, Yamada E, Saito T, Ohshima K, Hashimoto K, Yamada M, Uehara Y, Tsuchiya T, Shimizu H, Tatei K, Izumi T, Yamauchi K, Hisanaga S, Pessin JE, Mori M.
J Biol Chem. 2008 Dec 19;283(51):35455-63.

Identification of novel peptide agonists from a random peptide library for a 5-oxo-ETE receptor, a receptor for bioactive lipids.
Sasaki Y, Tsujii T, Takeda S, Obinata H, Izumi T, Yamada K, Katakai R.
J Pept Sci. 2008 Dec;14(12):1251-8.

Cell cycle control of telomere protection and NHEJ revealed by a ts mutation in the DNA-binding domain of TRF2.
Konishi A, de Lange T.
Genes Dev. 2008 May 1;22(9):1221-30.

Genetic background conversion ameliorates semi-lethality and permits behavioral analyses in cystathionine beta-synthase-deficient mice, an animal model for hyperhomocysteinemia.
Akahoshi N, Kobayashi C, Ishizaki Y, Izumi T, Himi T, Suematsu M, Ishii I.
Hum Mol Genet. 2008 Jul 1;17(13):1994-2005.

VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400.
Young AP, Schlisio S, Minamishima YA, Zhang Q, Li L, Grisanzio C, Signoretti S, Kaelin WG Jr.
Nat Cell Biol. 2008 Mar;10(3):361-9.

Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure.
Minamishima YA, Moslehi J, Bardeesy N, Cullen D, Bronson RT, Kaelin WG Jr.
Blood. 2008 Mar 15;111(6):3236-44

Escherichia coli cytosolic glycerophosphodiester phosphodiesterase (UgpQ) requires Mg2+, Co2+, or Mn2+ for its enzyme activity.
Ohshima N, Yamashita S, Takahashi N, Kuroishi C, Shiro Y, Takio K.
J Bacteriol.2008 Feb;190(4):1219-23.

G2A plays proinflammatory roles in human keratinocytes under oxidative stress as a receptor for 9-hydroxyoctadecadienoic acid.
Hattori T, Obinata H, Ogawa A, Kishi M, Tatei K, Ishikawa O, Izumi T.
J Invest Dermatol. 2008 May;128(5):1123-33.

pVHL acts as an adaptor to promote the inhibitory phosphorylation of the NF-kappaB agonist Card9 by CK2.
Yang H, Minamishima YA, Yan Q, Schlisio S, Ebert BL, Zhang X, Zhang L, Kim WY, Olumi AF, Kaelin WG Jr.
Mol Cell. 2007 Oct 12;28(1):15-27.

New insights into the binding mode of coenzymes: structure of Thermus thermophilus Delta1-pyrroline-5-carboxylate dehydrogenase complexed with NADP+.
Inagaki E, Ohshima N, Sakamoto K, Babayeva ND, Kato H, Yokoyama S, Tahirov TH.
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 2007 Jun 1;63(Pt 6):462-5.

Hypoxia-inducible factor linked to differential kidney cancer risk seen with type 2A and type 2B VHL mutations.
Li L, Zhang L, Zhang X, Yan Q, Minamishima YA, Olumi AF, Mao M, Bartz S, Kaelin WG Jr.
Mol Cell Biol. 2007 Aug;27(15):5381-92.

Purification and characterization of lysophospholipase D from rat brain.
Sugimoto S, Sugimoto H, Aoyama C, Aso C, Mori M, Izumi T.
Biochim Biophys Acta. 2006 Dec;1761(12):1410-8.

Differential induction of cystathionine gamma-lyase in the livers and kidneys of mouse dams during gestation and lactation.
Akahoshi N, Izumi T, Ishizaki Y, Ishii I.
Biol Pharm Bull. 2006 Sep;29(9):1799-802.

Crystal structure of Thermus thermophilus Delta1-pyrroline-5-carboxylate dehydrogenase.
Inagaki E, Ohshima N, Takahashi H, Kuroishi C, Yokoyama S, Tahirov TH.
J Mol Biol. 2006 Sep 22;362(3):490-501.

5-Oxo-eicosatetraenoic acid-induced chemotaxis: identification of a responsible receptor hGPCR48 and negative regulation by G protein G(12/13).
Koike D, Obinata H, Yamamoto A, Takeda S, Komori H, Nara F, Izumi T, Haga T.
J Biochem. 2006 Mar;139(3):543-9.

ACTH-secreting thymic carcinoid associated with multiple endocrine neoplasia type 1.
Yano M, Fukai I, Kobayashi Y, Mizuno K, Konishi A, Haneda H, Suzuki E, Endo K, Fujii Y.
Ann Thorac Surg. 2006 Jan;81(1):366-8.

Structure of ATP-dependent phosphoenolpyruvate carboxykinase from Thermus thermophilus HB8 showing the structural basis of induced fit and thermostability.
Sugahara M, Ohshima N, Ukita Y, Sugahara M, Kunishima N.
Acta Crystallogr D Biol Crystallogr. 2005 Nov;61(Pt 11):1500-7.

Identification of 9-hydroxyoctadecadienoic acid and other oxidized free fatty acids as ligands of the G protein-coupled receptor G2A.
Obinata H, Hattori T, Nakane S, Tatei K, Izumi T.
J Biol Chem. 2005 Dec 9;280(49):40676-83.

Epidermal growth factor receptor gene mutation in non-small cell lung cancer using highly sensitive and fast TaqMan PCR assay.
Endo K, Konishi A, Sasaki H, Takada M, Tanaka H, Okumura M, Kawahara M, Sugiura H, Kuwabara Y, Fukai I, Matsumura A, Yano M, Kobayashi Y, Mizuno K, Haneda H, Suzuki E, Iuchi K, Fujii Y.
Lung Cancer. 2005 Dec;50(3):375-84.

Stress-induced nuclear export of 5-lipoxygenase.
Hanaka H, Shimizu T, Izumi T.
Biochem Biophys Res Commun. 2005 Dec 9;338(1):111-6.

An atypical protein kinase C, PKC zeta, regulates human eosinophil effector functions.
Kato M, Yamaguchi T, Tachibana A, Suzuki M, Izumi T, Maruyama K, Hayashi Y, Kimura H.
Immunology. 2005 Oct;116(2):193-202.

Depletion of Chk1 leads to premature activation of Cdc2-cyclin B and mitotic catastrophe.
Niida H, Tsuge S, Katsuno Y, Konishi A, Takeda N, Nakanishi M.
J Biol Chem. 2005 Nov 25;280(47):39246-52.

Sp1 is a co-activator with Ets-1, and Net is an important repressor of the transcription of CTP:phosphocholine cytidylyltransferase alpha.
Sugimoto H, Okamura K, Sugimoto S, Satou M, Hattori T, Vance DE, Izumi T.
J Biol Chem. 2005 Dec 9;280(49):40857-66.

Crystal structure of novel NADP-dependent 3-hydroxyisobutyrate dehydrogenase from Thermus thermophilus HB8.
Lokanath NK, Ohshima N, Takio K, Shiromizu I, Kuroishi C, Okazaki N, Kuramitsu S, Yokoyama S, Miyano M, Kunishima N.
J Mol Biol. 2005 Sep 30;352(4):905-17.

EGFR Mutation status in Japanese lung cancer patients: genotyping analysis using LightCycler.
Sasaki H, Endo K, Konishi A, Takada M, Kawahara M, Iuchi K, Matsumura A, Okumura M, Tanaka H, Kawaguchi T, Shimizu T, Takeuchi H, Yano M, Fukai I, Fujii Y.
Clin Cancer Res. 2005 Apr 15;11(8):2924-9.

Structure of aldolase from Thermus thermophilus HB8 showing the contribution of oligomeric state to thermostability.
Lokanath NK, Shiromizu I, Ohshima N, Nodake Y, Sugahara M, Yokoyama S, Kuramitsu S, Miyano M, Kunishima N.
Acta Crystallogr D Biol Crystallogr. 2004 Oct;60(Pt 10):1816-23.

Structure of Thermus thermophilus 2-Keto-3-deoxygluconate kinase: evidence for recognition of an open chain substrate.
Ohshima N, Inagaki E, Yasuike K, Takio K, Tahirov TH..
J Mol Biol. 2004 Jul 9;340(3):477-89.

Skp2-mediated degradation of p27 regulates progression into mitosis.
Nakayama K, Nagahama H, Minamishima YA, Miyake S, Ishida N, Hatakeyama S, Kitagawa M, Iemura S, Natsume T, Nakayama KI.
Dev Cell. 2004 May;6(5):661-72.

Crystallographic structure and biochemical analysis of the Thermus thermophilus osmotically inducible protein C.
Rehse PH, Ohshima N, Nodake Y, Tahirov TH.
J Mol Biol. 2004 May 14;338(5):959-68.

Elevated serum epidermal growth factor receptor level in stage IV thymoma.
Sasaki H, Yukiue H, Sekimura A, Mizuno K, Konishi A, Yano M, Fukai I, Fujii Y.
Surg Today. 2004 34(5):477-9.

Crystal structure of purine nucleoside phosphorylase from Thermus thermophilus.
Tahirov TH, Inagaki E, Ohshima N, Kitao T, Kuroishi C, Ukita Y, Takio K, Kobayashi M, Kuramitsu S, Yokoyama S, Miyano M.
J Mol Biol. 2004 Apr 9;337(5):1149-60.

Endostatin gene transfection using a cationic lipid: advantages of transfection before tumor cell inoculation and repeated transfection.
Yano M, Nakashima Y, Kobayashi Y, Mizuno K, Konishi A, Sasaki H, Fukai I, Scheule RK, Fujii Y.
Cancer Gene Ther. 2004 May;11(5):354-62.

Expression of Smac/DIABLO is a novel prognostic marker in lung cancer.
Sekimura A, Konishi A, Mizuno K, Kobayashi Y, Sasaki H, Yano M, Fukai I, Fujii Y.
Oncol Rep. 2004 Apr;11(4):797-802.

ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway.
Ohtsuka T, Ryu H, Minamishima YA, Macip S, Sagara J, Nakayama KI, Aaronson SA, Lee SW.
Nat Cell Biol. 2004 Feb;6(2):121-8.

Involvement of histone H1.2 in apoptosis induced by DNA double-strand breaks.
Konishi A, Shimizu S, Hirota J, Takao T, Fan Y, Matsuoka Y, Zhang L, Yoneda Y, Fujii Y, Skoultchi AI, Tsujimoto Y.
Cell. 2003 Sep 19;114(6):673-88.

Glucocorticoids up-regulate leukotriene B4 receptor-1 expression during neutrophilic differentiation of HL-60 cells.
Obinata H, Yokomizo T, Shimizu T, Izumi T.
Biochem Biophys Res Commun. 2003 Sep 12;309(1):114-9.

Actin assembly is a crucial factor for superoxide anion generation from adherent human eosinophils.
Suzuki M, Kato M, Hanaka H, Izumi T, Morikawa A.
J Allergy Clin Immunol. 2003 Jul;112(1):126-33.

Elevated serum epidermal growth factor receptor level is correlated with lymph node metastasis in lung cancer.
Sasaki H, Yukiue H, Mizuno K, Sekimura A, Konishi A, Yano M, Kaji M, Kiriyama M, Fukai I, Yamakawa Y, Fujii Y.
Int J Clin Oncol. 2003 Apr;8(2):79-82.

Cten mRNA expression was correlated with tumor progression in lung cancers.
Sasaki H, Moriyama S, Mizuno K, Yukiue H, Konishi A, Yano M, Kaji M, Fukai I, Kiriyama M, Yamakawa Y, Fujii Y.
Lung Cancer. 2003 May;40(2):151-5.

Modulation of p53 and p73 levels by cyclin G: implication of a negative feedback regulation.
Ohtsuka T, Ryu H, Minamishima YA, Ryo A, Lee SW.
Oncogene. 2003 Mar 20;22(11):1678-87.

Identification of Ets-1 as an important transcriptional activator of CTP:phosphocholine cytidylyltransferase alpha in COS-7 cells and co-activation with transcriptional enhancer factor-4.
Sugimoto H, Sugimoto S, Tatei K, Obinata H, Bakovic M, Izumi T, Vance DE.
J Biol Chem. 2003 May 30;278(22):19716-22. Epub 2003 Mar 17.

Tumor suppression through angiogenesis inhibition by SUIT-2 pancreatic cancer cells genetically engineered to secrete NK4.
Saimura M, Nagai E, Mizumoto K, Maehara N, Minamishima YA, Katano M, Matsumoto K, Nakamura T, Tanaka M.
Clin Cancer Res. 2002 Oct;8(10):3243-9.

Inhibition of protein kinases A and C demonstrates dual modes of response in human eosinophils stimulated with platelet-activating factor.
Takizawa T, Kato M, Kimura H, Suzuki M, Tachibana A, Obinata H, Izumi T, Tokuyama K, Morikawa A.
J Allergy Clin Immunol. 2002 Aug;110(2):241-8.

Leukotriene receptors: classification, gene expression, and signal transduction.
Izumi T, Yokomizo T, Obinata H, Ogasawara H, Shimizu T.
J Biochem. 2002 Jul;132(1):1-6.

Recovery of liver mass without proliferation of hepatocytes after partial hepatectomy in Skp2-deficient mice.
Minamishima YA, Nakayama K, Nakayama K.
Cancer Res. 2002 Feb 15;62(4):995-9.

Nuclear-localization-signal-dependent and nuclear-export-signal-dependent mechanisms determine the localization of 5-lipoxygenase.
Hanaka H, Shimizu T, Izumi T.
Biochem J. 2002 Feb 1;361(Pt 3):505-14.

Receptor-dependent metabolism of platelet-activating factor in murine macrophages.
Ohshima N, Ishii S, Izumi T, Shimizu T.
J Biol Chem. 2001 Mar 22;277(12):9722-7.

Effect of serum depletion on centrosome overduplication and death of human pancreatic cancer cells after exposure to radiation.
Shono M, Sato N, Mizumoto K, Minamishima YA, Nakamura M, Maehara N, Urashima T, Saimura M, Qian L, Nishio S, Nagai E, Tanaka M.
Cancer Lett. 2001 Sep 10;170(1):81-9.

Correlation between centrosome abnormalities and chromosomal instability in human pancreatic cancer cells.
Sato N, Mizumoto K, Nakamura M, Maehara N, Minamishima YA, Nishio S, Nagai E, Tanaka M.
Cancer Genet Cytogenet. 2001 Apr 1;126(1):13-9.

Identification of transcriptional enhancer factor-4 as a transcriptional modulator of CTP:phosphocholine cytidylyltransferase alpha.
Sugimoto H, Bakovic M, Yamashita S, Vance DE.
J Biol Chem. 2001 Apr 13;276(15):12338-44.

Down-regulation of p27Kip1 expression is required for development and function of T cells.
Tsukiyama T, Ishida N, Shirane M, Minamishima YA, Hatakeyama S, Kitagawa M, Nakayama K, Nakayama K.
J Immunol. 2001 Jan 1;166(1):304-12.

Activation of mucosal phospholipase D in a rat model of colitis.
Sakamoto T, Okamura S, Saruya SY, Yamashita S, Mori M.
J Gastroenterol Hepatol. 2000 Oct;15(10):1138-44.

A possible role for centrosome overduplication in radiation-induced cell death.
Sato N, Mizumoto K, Nakamura M, Ueno H, Minamishima YA, Farber JL, Tanaka M.
Oncogene. 2000 Nov 2;19(46):5281-90.

Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice.
Takai H, Tominaga K, Motoyama N, Minamishima YA, Nagahama H, Tsukiyama T, Ikeda K, Nakayama K, Nakanishi M, Nakayama K.
Genes Dev. 2000 Jun 15;14(12):1439-47.

Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication.
Nakayama K, Nagahama H, Minamishima YA, Matsumoto M, Nakamichi I, Kitagawa K, Shirane M, Tsunematsu R, Tsukiyama T, Ishida N, Kitagawa M, Nakayama K, Hatakeyama S.
EMBO J. 2000 May 2;19(9):2069-81.

Characterization of the transacylase activity of rat liver 60-kDa lysophospholipase-transacylase. Acyl transfer from the sn-2 to the sn-1 position.
Sugimoto H, Yamashita S.
Biochim Biophys Acta. 1999 May 18;1438(2):264-72.

Sequence, expression in Escherichia coli, and characterization of lysophospholipase II.
Toyoda T, Sugimoto H, Yamashita S.
Biochim Biophys Acta. 1999 Feb 25;1437(2):182-93.

Enhanced levels of oleate-dependent and Arf-dependent phospholipase D isoforms in experimental colon cancer.
Yoshida M, Okamura S, Kodaki T, Mori M, Yamashita S.
Oncol Res. 1998;10(8):399-406.

Cloning and expression of cDNA encoding rat liver 60-kDa lysophospholipase containing an asparaginase-like region and ankyrin repeat.
Sugimoto H, Odani S, Yamashita S.
J Biol Chem. 1998 May 15;273(20):12536-42.

Identification of lipid inhibitor of mammalian phospholipase D.
Kawabe K, Kodaki T, Katayama K, Okamura S, Mori M, Yamashita S.
J Biochem. 1998 May;123(5):870-5.

Cloning, differential regulation and tissue distribution of alternatively spliced isoforms of ADP-ribosylation-factor-dependent phospholipase D from rat liver.
Katayama K, Kodaki T, Nagamachi Y, Yamashita S.
Biochem J. 1998 Feb 1;329 ( Pt 3)(Pt 3):647-52.

Phosphatidylserine synthase from yeast.
Yamashita S, Nikawa J.
Biochim Biophys Acta. 1997 Sep 4;1348(1-2):228-35.

Choline kinase from yeast.
Yamashita S, Hosaka K.
Biochim Biophys Acta. 1997 Sep 4;1348(1-2):63-9.

Differential distribution of mRNAs encoding phosphatidylinositol transfer proteins alpha and beta in the central nervous system of the rat.
Imai H, Tanaka S, Fukusato T, Yamashita S, Hosaka K.
Brain Res Mol Brain Res. 1997 Jun;46(1-2):256-64.

Cloning, expression, and characterization of a novel phospholipase D complementary DNA from rat brain.
Kodaki T, Yamashita S.
J Biol Chem. 1997 Apr 25;272(17):11408-13.

Increased phospholipase D activity in human breast cancer.
Uchida N, Okamura S, Nagamachi Y, Yamashita S.
J Cancer Res Clin Oncol. 1997;123(5):280-5.

Molecular cloning of rat phosphatidylinositol synthase cDNA by functional complementation of the yeast Saccharomyces cerevisiae pis mutation.
Tanaka S, Nikawa J, Imai H, Yamashita S, Hosaka K.
FEBS Lett. 1996 Sep 9;393(1):89-92.

Purification, cDNA cloning, and regulation of lysophospholipase from rat liver.
Sugimoto H, Hayashi H, Yamashita S.
J Biol Chem. 1996 Mar 29;271(13):7705-11.

Cloning and expression of human cDNA encoding phosphatidylinositol transfer protein beta.
Tanaka S, Yamashita S, Hosaka K.
Biochim Biophys Acta. 1995 Dec 7;1259(3):199-202.

Specificity of Rel-inhibitor interactions in Drosophila embryos.
Tatei K, Levine M.
Mol Cell Biol. 1995 Jul;15(7):3627-34.

Purification and properties of lysophospholipase isoenzymes from pig gastric mucosa.
Sunaga H, Sugimoto H, Nagamachi Y, Yamashita S.
Biochem J. 1995 Jun 1;308 ( Pt 2)(Pt 2):551-7.

Race: a Drosophila homologue of the angiotensin converting enzyme.
Tatei K, Cai H, Ip YT, Levine M.
Mech Dev. 1995 Jun;51(2-3):157-68.

The SNF2/SWI2/GAM1/TYE3/RIC1 gene is involved in the coordinate regulation of phospholipid synthesis in Saccharomyces cerevisiae.
Kodaki T, Hosaka K, Nikawa J, Yamashita S.
J Biochem. 1995 Feb;117(2):362-8.

Purification and characterization of phosphatidylcholine phospholipase D from pig lung.
Okamura S, Yamashita S.
J Biol Chem. 1994 Dec 9;269(49):31207-13.

Cloning and sequence of the SCS3 gene which is required for inositol prototrophy in Saccharomyces cerevisiae.
Hosaka K, Nikawa J, Kodaki T, Ishizu H, Yamashita S.
J Biochem. 1994 Dec;116(6):1317-21.

Purification, characterization, and inhibition by phosphatidic acid of lysophospholipase transacylase from rat liver.
Sugimoto H, Yamashita S.
J Biol Chem. 1994 Feb 25;269(8):6252-8.

Cloning and characterization of the SCS1 gene required for the expression of genes in yeast phospholipid synthesis.
Hosaka K, Nikawa J, Kodaki T, Yamashita S.
J Biochem. 1994 Jan;115(1):131-6.

Dif, a dorsal-related gene that mediates an immune response in Drosophila.
Ip YT, Reach M, Engstrom Y, Kadalayil L, Cai H, González-Crespo S, Tatei K, Levine M.
Cell. 1993 Nov 19;75(4):753-63.

Cloning of a human choline kinase cDNA by complementation of the yeast cki mutation.
Hosaka K, Tanaka S, Nikawa J, Yamashita S.
FEBS Lett. 1992 Jun 15;304(2-3):229-32.

IRE1 encodes a putative protein kinase containing a membrane-spanning domain and is required for inositol phototrophy in Saccharomyces cerevisiae.
Nikawa J, Yamashita S.
Mol Microbiol. 1992 Jun;6(11):1441-6.

Molecular cloning, characterization, and expression in Escherichia coli of a cDNA encoding mammalian choline kinase.
Uchida T, Yamashita S.
J Biol Chem. 1992 May 15;267(14):10156-62.

A dominant mutation that alters the regulation of INO1 expression in Saccharomyces cerevisiae.
Hosaka K, Nikawa J, Kodaki T, Yamashita S.
J Biochem. 1992 Mar;111(3):352-8.

Functional analysis of the regulatory region of the yeast phosphatidylserine synthase gene, PSS.
Kodaki T, Nikawa J, Hosaka K, Yamashita S.
J Bacteriol. 1991 Dec;173(24):7992-5.

Isolation and characterization of two distinct myo-inositol transporter genes of Saccharomyces cerevisiae.
Nikawa J, Tsukagoshi Y, Yamashita S.
J Biol Chem. 1991 Jun 15;266(17):11184-91.

Expression in Escherichia coli of the Saccharomyces cerevisiae CCT gene encoding cholinephosphate cytidylyltransferase.
Tsukagoshi Y, Nikawa J, Hosaka K, Yamashita S.
J Bacteriol. 1991 Mar;173(6):2134-6.

Identification of the upstream activation sequences responsible for the expression and regulation of the PEM1 and PEM2 genes encoding the enzymes of the phosphatidylethanolamine methylation pathway in Saccharomyces cerevisiae.
Kodaki T, Hosaka K, Nikawa J, Yamashita S.
J Biochem. 1991 Feb;109(2):276-87.

Primary structure of the yeast choline transport gene and regulation of its expression.
Nikawa J, Hosaka K, Tsukagoshi Y, Yamashita S.
J Biol Chem. 1990 Sep 15;265(26):15996-6003.

Purification and properties of choline kinase from rat brain.
Uchida T, Yamashita S.
Biochim Biophys Acta. 1990 Apr 17;1043(3):281-8.

Repression of choline kinase by inositol and choline in Saccharomyces cerevisiae.
Hosaka K, Murakami T, Kodaki T, Nikawa J, Yamashita S.
J Bacteriol. 1990 Apr;172(4):2005-12.

Characterization of the methyltransferases in the yeast phosphatidylethanolamine methylation pathway by selective gene disruption.
Kodaki T, Yamashita S.
Eur J Biochem. 1989 Nov 6;185(2):243-51.

Interconversion of polyamines in wild-type strains and mutants of yeasts and the effects of polyamines on their growth.
Hamana K, Matsuzaki S, Hosaka K, Yamashita S.
FEMS Microbiol Lett. 1989 Oct 1;52(1-2):231-6.

New methods to investigate ATP requirement for pre-mRNA splicing: inhibition by hexokinase/glucose or an ATP-binding site blocker.
Tatei K, Kimura K, Ohshima Y.
J Biochem. 1989 Sep;106(3):372-5.

Cloning and characterization of the yeast CKI gene encoding choline kinase and its expression in Escherichia coli.
Hosaka K, Kodaki T, Yamashita S.
J Biol Chem. 1989 Feb 5;264(4):2053-9.

Expression of the Saccharomyces cerevisiae PIS gene and synthesis of phosphatidylinositol in Escherichia coli.
Nikawa J, Kodaki T, Yamashita S.
J Bacteriol. 1988 Oct;170(10):4727-31.

Molecular cloning and characterization of the gene encoding cholinephosphate cytidylyltransferase in Saccharomyces cerevisiae.
Tsukagoshi Y, Nikawa J, Yamashita S.
Eur J Biochem. 1987 Dec 15;169(3):477-86.

Yeast phosphatidylethanolamine methylation pathway. Cloning and characterization of two distinct methyltransferase genes.
Kodaki T, Yamashita S.
J Biol Chem. 1987 Nov 15;262(32):15428-35.

Recognition of 5′ and 3′ splice site sequences in pre-mRNA studied with a filter binding technique.
Tatei K, Takemura K, Tanaka H, Masaki T, Ohshima Y.
J Biol Chem. 1987 Aug 25;262(24):11667-74.

Three distinct activities possibly involved in mRNA splicing are found in a nuclear fraction lacking U1 and U2 RNA.
Mayeda A, Tatei K, Kitayama H, Takemura K, Ohshima Y.
Nucleic Acids Res. 1986 Apr 11;14(7):3045-57.

Messenger RNA splicing: role of small nuclear RNA-protein complexes.
Ohshima Y, Tatei K, Takemura K, Mayeda A, Kitayama H.
Adv Biophys. 1986;21:255-65.

U1 RNA-protein complex preferentially binds to both 5′ and 3′ splice junction sequences in RNA or single-stranded DNA.
Tatei K, Takemura K, Mayeda A, Fujiwara Y, Tanaka H, Ishihama A, Ohshima Y.
Proc Natl Acad Sci U S A. 1984 Oct;81(20):6281-5.

Activation of rat liver choline kinase by polyamines.
Fukuyama H, Yamashita S.
FEBS Lett. 1976 Nov 15;72(1):33-6.

Studies on the Kielley-Meyerhof ATPase with special reference to the effect of cations on it.
Shimizu S, Katagiri A, Yamazoe S.
Gunma J Med Sci. 1969 Dec;17(1):1-10.

Studies on brain phospholipids. IV. Post-mortem breakdown of phosphoinositides and phosphatidic acid, and P32-incorporation into phospholipids in various states of the tissue.
Hayashi K, Yagihara Y, Nakamura I, Yamazoe S.
J Biochem. 1966 Jul;60(1):42-51.

Presence of sodium-potassium-stimulated ATPase in boar epididymal spermatozoon.
Uesugi S, Yamazoe S.
Nature. 1966 Jan 22;209(5021):403.

Deamination of L-Thyroxine by Oxidase and Transaminase of Rat Kidney Mitochondria.
Nakano M, Tsuchiya S, Shimizu S, Yamazoe S, Danowski TS.
Endocrinology. 1963 Aug;73:237-43.

Studies on the brain phospholipids. II. The effect of electrically induced convulsions on the incorporation of P32 into rabbit brain phospholipids.
Hayashi K, Kanoh T, Shimizu S, Kai M, Yamazoe S.
J Biochem. 1962 Jan;51:72-7.

Studies on the brain phospholipids. I. Incorporation of P32 into phospholipids in guinea-pig brain slices.
Hayashi K, Kanoh T, Shimizu S, Kai M, Yamazoe S.
J Biochem. 1962 Jan;51:63-71.

Studies on the incorporation of P32-labelled orthophosphate into the phosphatides of heart and femoral muscle of rat.
Hayashi K, Kanoh T, Yamazoe S.
J Biochem. 1961 Sep;50:202-9.

A positive feedback mechanism of adenosine triphosphate synthesis in erythrocytes.
Nakao M, Motegi T, Nakao T, Yamazoe S, Yoshikawa H.
Nature. 1961 Jul 15;191:283-4.

Adenosine triphosphate and shape of erythrocytes.
Nakao M, Nakao T, Yamazoe S, Yoshikawa H.
J Biochem. 1961 Jun;49:487-92.

Adenosine triphosphate and maintenance of shape of the human red cells.
Nakao M, Nakao T, Yamazoe S.
Nature. 1960 Sep 10;187:945-6.

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