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Our research goal is to elucidate the following molecular mechanisms:

(1) Hypoxic response

(2) Lipid metabolism

(3) DNA damage response

(4) Cancer-specific metabolism

(5) Cellular senescence

Our experimental strategy includes biochemistry, molecular biology, cell biology, analytical chemistry, and genetics (mouse and fly).

【Keywords】
The hypoxic response, Lipid mediator, Receptor, Signal transduction, DNA damage, Omics analysis


(1) The molecular mechanism of regulation of cellular energy metabolism by the hypoxic response

The hypoxic response is involved in many physiological events including metabolism, epigenetics, transcription, respiration, and redox. These are closely related to ischemia/reperfusion injury, ischemic heart disease, chronic kidney disease, obesity, cancer, and inflammation. Our lab is trying to elucidate the mechanism of metabolism regulation by the hypoxic response in vivo.

The Nobel Prize in Physiology or Medicine 2019 was awarded to Drs. William G. Kaelin Jr, Sir Peter J. Ratcliffe, and Gregg L. Semenza for their discoveries of "how cells sense and adapt to oxygen availability". Now you could tell that hypoxia biology is one of the most important, most interesting, and hottest research fields.

2019年ノーベル生理学・医学賞

It was great honor that our research was featured at the Nobel Prize Lecture 2019.

(2) Regulation of lipid metabolism

Bioactive lipids are produced from membrane phospholipids upon various stimuli and act on their specific cell-surface receptors (G-protein coupled receptor; GPCR) of neighborhood cells. They are involved in most life activity such as nervous system, respiration, circulation, reproduction, and cell differentiation. In our department, biochemical research on phospholipid metabolism and lipid mediator is conducted. Our research project aims to clarify turnover of cell membrane phospholipids on various kinds of stimulation, production of bioactive lipids (leukotriene, LPA, 2-AG, 9-HODE), signal transduction through their GPCRs, and function of these bioactive lipids.

(3) Response upon DNA damage

Our lab focuses on the maintenance of telomere and response upon DNA damage, trying to unveil the whole molecular mechanism of DNA-damage/DNA-repair signaling using the techniques including molecular biology, biochemistry, and proteomics using mass spectrometry.

(4) Cancer cell-specific metabolism system

We have already identified the several metabolites that might be involved in cancer cell-specific energy metabolism system. Our goal is to develop a new treatment strategy against cancer that targets the cancer-specific metabolism pathway.

(5) Molecular mechanism of cellular senescence

B Based on our preliminary metabolome analysis, we have identified several cell senescence-specific metabolites. The project aims to clarify the whole picture of cellular senescence form the view of cellular metabolism.


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